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KMID : 0351619720130020147
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Kyungpook Medical Journal
1972 Volume.13 No. 2 p.147 ~ p.155
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Peroxidase Activity of Granules of Polymorphonuclear Leukocytes on the Electron Microscopic Level
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Abstract
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It is evident that neutrophils participate in an important role in body defense mechanisms.
The neutrophilic granules -lysosome- are thought as main machinery in the processes of digestion of phagacytized foreign materials. The polymorphonuclear leukocyte granules were investi-gated by examining developing granulocyte from normal rabbit bone marrow, in order to study how they exist, from where they are derived and how they develop. In addition, peroxidase activity was scored - at electron microscopic level.
The results were:
Two distinct types of granules, azurophil and specific, were distinguished on the bases of their differences in size, density and time of origin. Both types originated from Golgi complex, but azurophil granules originated in the progranulocyte stage and specific granules originated in the myelocyte stage. No transforming features were found between the two types. The azurophil granules decreased in number throughout successive maturation stages. Azurophil granules were more dense and larger than specific granules.
Peroxidase activity was found in both immature and mature azurophil granules but specific granules and lumen of rER and Golgi complex failed to demonstrate the peroxidase activity.
Reaction patterns were different in individual azurophil granules which suggested heterogeneity of the granues.
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KEYWORD
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